TFF System - ZETA BIOSYSTEM

Tangential Flow Filtration (TFF) System

A TFF (Tangential Flow Filtration) system is a filtration technology used for the separation and purification of biomolecules, such as proteins, nucleic acids, and viruses, from a liquid solution. Unlike traditional filtration, where fluid flows perpendicular to the filter membrane, TFF involves fluid flowing parallel to the membrane surface. This design helps prevent clogging by sweeping away particles and ensures efficient separation

Usage

TFF systems are widely used in the biotechnology and pharmaceutical industries due to their scalability, efficiency, and ability to handle sensitive biomolecules

Filtration Principle

Tangential Flow: The feed solution flows parallel to the membrane surface, reducing fouling and allowing continuous filtration.

Permeate and Retentate Streams: Permeate passes through the membrane, while retentate circulates back for further filtration.

Features

Design

Scalability: Systems range from lab-scale units to large-scale industrial setups.

Cartridge and Cassette Compatibility: Modular membranes allow flexibility and easy replacement.

Customizable Configurations: Designed to meet specific process needs, such as single-pass or batch operations.

Instrumentation

Flow Sensors: Measure retentate and permeate flow rates.

Pressure Gauges: Monitor feed, retentate, and permeate pressures.

Temperature Sensors: Ensure membrane performance within safe temperature ranges.

Conductivity and pH Sensors: Monitor product quality during diafiltration.

Automation

PLC Integration: Automates flow rate, pressure control, and cleaning cycles.

HMI Interface: Touchscreen control for system operation and monitoring.

Data Logging: Tracks process parameters for validation and troubleshooting.

Scalability

Lab to Production Scale: Systems can scale seamlessly from R&D to full-scale manufacturing.

Parallel Processing: Multiple modules can operate simultaneously for increased throughput.

Adaptability

Applications: Protein concentration, buffer exchange, cell harvest, or virus filtration.

Fluid Types: Suitable for liquids containing proteins, cells, or particles.

Wide Range of Molecular Weights: Tailored for different separation requirements.

Maintenance

CIP (Clean-in-Place) Systems: Automated cleaning for minimal downtime and manual intervention.

Backflushing: Removes fouling and restores membrane performance.

Easy Access: Quick-release clamps or flanged connections for fast filter media replacement.

Drain-ability: Properly designed to ensure complete removal of fluids during cleaning or maintenance.

ZETA BIOSYSTEM PRIVATE LIMITED

(Formerly know as BPE BIOTREE INDIA PRIVATE LIMITED)

Team Zetabiosystem has emerged as one of the leading Bioprocess Engineering Company in the global market. with a footprint in over 15 countries, we stand as the leader for over 20years. Quality by design has always been our goal and continues even today.